Osteoporosis is a skeletal disorder distinguished by micro architectural deterioration and rapid bone loss at the osseous tissue, increasing the risk for bone fracture especially at the hip, wrist, and spine. Knowledge, Attitude and Practices (KAP) is a quantitative method that provides access to quantitative and qualitative information. The study aimed to assess the level of Knowledge, Attitude and Practice regarding Osteoporosis among adult patients in Bashair University Hospital 202l. Methodology: This was descriptive cross-sectional hospital-based study conducted in Bashair Hospital 2021. 200 participants were chosen. Data were collected using designed interview questionnaire. Statistical package for social sciences version 26 used for analysis. Results: (53.5%) of participants were females. (33.0%) of participants their level of educational is basic school. (45.2%) of the participants had poor knowledge, (40%) of the participants had poor attitude, and (54%) of the participants had moderate practice about Osteoporosis among adult patients. There was a significant relation between age groups and level of educational regarding Knowledge, Attitude and Practice (p≤ .001). There was a significant relation between Knowledge and Attitude (P<.001) and Knowledge and Practice (P<.001). Conclusion: The study concluded that adult patients had poor knowledge, attitude and moderate practice regarding Osteoporosis. Factors such as age, level of educational and gender were significantly influence the level of knowledge, attitude and practice. Recommendation: Upraise the level of awareness; establish screening programs for community population especially in low socioeconomic areas, regular investigations and at least once for bone scanning regarding Osteoporosis.