Background: Clinical settings provides a real-world environment in which students can safely translate theoretical nursing knowledge into practical nursing care, while simultaneously developing the attitudes and skills that are essential to the profession (Galletta, M. et al., 2017). Since perception of students is an influential factor in determining safety in clinical settings and in any educational value in clinical settings, students must follow educationally sound behaviors such as participation, interaction, communication, feedback, and transparency that our true religion has urged this study aimed to determine nursing students’ perception of communication and safety reporting. Methodology: This is a descriptive exploratory cross-sectional study conducted in Khartoum state at five recognized governmental universities, total coverage sampling method was used, included 470 nursing students in the 4th year 2017-2018 that met selection criteria, data collected by the researcher using published self administered survey then the collected data were analyzed included 470 respondents. Results: Among 519 nursing students included, a total of 470 students responded at a rate of 90.5% and responses showed that one third of them 162(34.5%) reported that students and nurses in the clinical settings sometimes discuss ways to prevent errors from happening while, 153(32.6%) never feel free to speak up if they see something that may negatively affect the patient safety and (34.9%) perceived that nurses were not appear free to speak up if they see something that may negatively affect the patient safety , hence near to half 232(49.4%) stressed that clinical instructor never discuss patient safety including the use of reporting tools, although 153(32.6%) of respondents perceived that they aware about errors made by themselves, other students or nurses but 148(31.5%) perceived that sometimes they are afraid to ask questions if something does not seem right. Fur