EAS Publisher | Seronegative Primary Biliary Cholangitis: Epidemiological, Clinical, Therapeutic and Progressive Features

Seronegative Primary Biliary Cholangitis: Epidemiological, Clinical, Therapeutic and Progressive Features

DOI : https://doi.org/10.36344/ccijmb.2020.v02i09.003

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Introduction: Seronegative PBC (specific AMA antibodies are negative) is a particular clinical form of PBC.The aim of this study was to determine the clinical-biological and evolutionary features of seronegative PBCs. Methods: The medical data of 42 PBC patients were evaluated and the AMA positive and negative groups were compared. Results: 42 cases of PBC were collected. These were 41 women and 1 man. The mean age at diagnosis was 46 years (25-70 years). AMA Abs were most often positive (n = 34). Other antibodies were found in 22 patients. In our series, 9.75% of cases had seronegative PBC. By comparing the 2 groups of PBC with or without AMA Abs, depending on age, sex, degree of fibrosis and response to AUDC, no statistically significant difference was noted. Conclusion: In our series, the prevalence of seronegative PBC was 9.75%. Its clinical-biological and evolutionary profile under treatment does not seem to differ from that of seropositive PBC.

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