EAS Publisher | Primary biliary cholangitis (PBC) - autoimmune hepatitis (HAI) overlap syndrome (OS)

Primary biliary cholangitis (PBC) - autoimmune hepatitis (HAI) overlap syndrome (OS)

DOI : https://doi.org/10.36344/ccijmb.2020.v02i09.001

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The AIH-PBC overlap syndrome is the most common form of OS. The aim: to study the clinical and paraclinical characteristics of the overlap syndrome and to specify the therapeutic and evolutionary characteristics. Methods: The medical data of 42 PBC patients were evaluated for associated autoimmune hepatitis. Results: Among the 42 cases of PBC, we retained 16 cases of OS (37%). All female the association of diagnostic criteria for PBC and HAI was simultaneous in 80%. Treatment with AUDC, corticosteroid and Azathioprine was started in the majority of our patients. The course was marked by a complete (10 cases) or incomplete (n = 6) response. Conclusion: OS should be considered in the presence of any mixed cytolytic and cholestatic liver disease. Its recognition is essential in order to adapt treatment and prevent progression to cirrhosis and its complications.

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