Objectives: Pelvic inflammatory disease (PID) refers to an infectious and inflammatory disorder of the female upper genital tract. It is common among young sexually active individuals and is a major health problem both in the developed and developing countries. It is usually a polymicrobial infection, however, Chlamydia trachomatis is the commonest causative agent transmitted sexually. PID is diagnosed by history and clinical examination. The treatment is initially empiric. Only Antibiotcs are good in treatment for PID and ‘Antibiotics with Prebiotics’ are new promising treatment mode for same. This comparative study aimed to measure efficiency and compliance of only Antibiotcs versus Antibiotics with Prebiotics in the treatment of mild, uncomplicated acute PID. Methods: A descriptive cross-sectional study was conducted in randomly selected 28 consecutive outpatients with mild uncomplicated acute PID. Comparative outcome of Antibiotics and Antibiotics with Prebiotics in correlation with reduction of amount, consistency and malodor of vaginal discharge along with reduction in fornical tenderness, compliance and frequency of adverse drug reactions was done. Results: Among 28 cases 14 (50%) were treated with oral Antibiotics and 14 (50%) with oral Antibiotics with Prebiotics. Comparative analysis on reduction of amount, consistency, malodor of vaginal discharge and reduction of fornical tenderness were significant, showing Antibiotics with Prebiotics more effective than Antibiotics. Conclusion: Antibiotics with Prebiotics has better efficiency and compliance over only Antibiotics in the treatment of mild, uncomplicated, acute PID.