The purpose of this study was to increase the effectiveness of treatment of chronic generalized periodontitis in patients with metabolic syndrome on the basis of studying clinical and laboratory parallels of the biochemical status of the oral cavity. 52 patients with CGP combined with MS were examined. At the age of 20-60 years, and also 14 people - practically healthy people of the same age. For the study were formed 2 groups of patients, each of which consisted of 26 people. Depending on various treatment methods, patients were randomly randomized to the following groups: group 1 - patients with chronic hepatitis C combined with MS, receiving standard treatment for periodontal disease using Timogil gel and Trinomy, 2 groups, and (comparison group) - patients receiving standard treatment of CGP. The diagnosis of MS was established by cardiologists on the basis of a comprehensive clinical and laboratory examination. The high efficacy of the proposed therapeutic and prophylactic complex in relation to impaired levels of triglycerides, cholesterol and glucose in the oral fluid of CGP patients with concomitant MS has been shown. The biochemical studies of the roto fluid of the observed patients with chronic generalized periodontitis indicated a lack of basic therapy in the treatment and prevention of complications of periodontal tissue diseases against the background of MS, and also confirmed the established high efficacy of the developed therapeutic and preventive complex.