Objective: To present the epidemiological, clinical and histological aspects of bladder cancer at the National Hospital of Zinder (Niger). Materials and methods: This is a retrospective, descriptive and analytical study covering the period from June 2014 to January 2022concerning the files of patients followed up for bladder cancer. The patients come from three regions bordering Zinder (Maradi, Agadez, Diffa). The parameters studied were epidemiology, age, sex, clinical signs, paraclinical tests, and histological results. Results: A total of 6724 patients were consulted during the period, which brings to 1.23% the incidence of bladder cancer at Zinder national hospital (HNZ). The median age of patients was 56.83 years with extremes of 24 and 77 years. The sex ratio was 7/1. A history of chronic smoking for an average of 5 pack-years was found in 8 cases (9.63%). Among the other risk factors, a history of urinary schistosomiasis in 58 cases (69.87%). The reasons for consultation were: total hematuria 63 cases (76.41%), permanent pollakiuria 8 cases (9.32%), acute urine retention 7 cases (8.33%), renal failure 3 cases (3.54%), exophytic tumor 2 cases (2.40%). Additional diagnostic tests were: ultrasound, cystoscopy, computed tomography (CT). Histology found 66 cases (79.51%) of squamous cell carcinoma, 15 cases (18.07%) of urothelial carcinoma and 2 cases (2.42%) of adenocarcinoma.