Diabetes is an opportunistic killer. Approximately 77 million people in India suffer from diabetes. A person develops diabetes due to genetic predisposition, family history, obesity, lack of physical activity, diet low in fruits and vegetables. Modification of life style and pharmacotherapy of diabetes are often indicated to control diabetes and emergence of complications. Therefore, the present study was undertaken to evaluate the prescription pattern of anti diabetic drugs among indoor patient with adherence to WHO core prescribing indicator. This was a prospective observational study. All the relevant data were collected and drug utilization pattern of AHA was determined. Direct cost associated with the use of ant hyperglycemic medicines was calculated and consumption of the ant hyperglycemic medicines was measured as defined daily dose (DDD)/100 bed-days. The adverse drug reactions (ADRs) related to anti-diabetic medicines was monitored. In the present study, 99 (50.3%) of the 197 diabetic patients were males. Majority of patients were in the age group of 51-60 years (39.6%) and most of the patients (36.5%) had a diabetic history of <5 years. Metformin was the most commonly prescribed drug (68%), followed by sulfonylurea class of drugs (49.7%). Nearly, 42% patients were using insulin preparations with 30.4% using biphasic isophane human insulin. Majority of the patients (58.4%) were on multidrug therapy with two drug therapies being received by nearly 40%. Metformin was the most commonly prescribed drug in monotherapy (18.8%) and glimepiride + metformin was the most common two drug therapy (13.2%). Co-morbid condition was found in 172 patients (87.3%) with hypertension (68.5%) being the most common co-morbid condition. 17 ADRs were observed with hypoglycemia being the most common ADR reported. To conclude, the study reveals that Metformin continues to be the choice of oral hypoglycemic agents with least adverse effects and insulin was used to treat uncontrolled