Background: More than half of all maternal deaths occur within 24 hrs. of delivery and most commonly occur from excessive blood loss. PPH is the most significant direct cause of maternal mortality in low resource countries, accounting for approximately 30% of maternal deaths worldwide and is one of the most preventable. This study finds out to use of oral misoprostol in active management of the third stage of labour. Objective: To use oral misoprostol for active management of the third stage of labour. Method: An Observational cross-sectional study was carried out Obstetrics & Gynaecology indoor Department of BSMMU, from November ‘2013 to April’ 2014, 100 cases were included in this study. Detailed information’s were obtained in each cases according to protocol. Complete history was taken either from patient or accompanying attendants. Thorough clinical examination was done. Relevant investigations report was collected. All the information’s were recorded in the fixed protocol. Collected data was classified, edited, coded and entered into the computer for statistical analysis by using SPSS. RESULTS: In present study 100 cases were included, the mean age was 27.64(±4.25) years, minimum age was 20 years and maximum age was 40 years. Twenty seven percent were come from lower socio-economic class, 69% came from middle class and only 04% came from upper socio-economic class. Thirty four percent were primi para, 49% were 1-3 para and 07% were > 3 para. Mean duration of third stage of labour 7.49(±2.82) min. Six percent need additional oxytocics and 94% do not need additional drug. Pre delivery mean systolic blood pressure was 119.3 ±10.4 mm of Hg and mean diastolic blood pressure was 69.57 ± 6.23 mm of Hg. Mean Hb% level was 12.1 ± 1.3 g/dl and minimum level was 7.5 g/dl and 13.8 g/dl. 06% patients had blood loss > 500 ml. No side effects such as vomiting diarrhea. However, shivering occurred 08%, fever 07% and nausea was found 03% patients. ...................