Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous units which has great psychological impact and causes depression, anxiety, and low self-esteem. Objective: To assess the impact of acne on Quality of Life and acne vulgaris is a chronic disease affecting the face in adolescents and adults. Material and Methods: This study has been conducted in the Dermatology & Venereology Clinic of COMFORT DOCTORS Chamber & Consultation Centre, Uttara, Dhaka, Bangladesh. The study sample consisted of 501 consecutive patients with facial acne vulgaris who had attended the Dermatology Clinic over a period of 6 months from January to June-2018. The subjects with pre-existing psychiatry disorders were excluded. A detailed history regarding socio demographic profile, symptoms and clinical aspects was taken after obtaining consent from all the participants of the study. Results: Out of 501 patients, majority 52.4% belonged to 16-20 years age group. Only 13.77% patients belonged to the >30 years age group (Table 1). Majority of patients, i.e. 52% were females and only 48% were males. Majority of the patients were educated (74.45%) and unmarried (68.06%). Most of the participants (61.47%) were from the urban areas. 299 patients (59.68%) had an acne duration of >1 year. In 334 patients (66.66%) the CADI scores were >8 showing a clear impact on QOL. Severe acne was seen in 29.54% of patients and 48.7%, 21.75 had a moderate, mild grade of acne. Based on the DLQI scores 74.83% of the patients had a moderate to extremely large impairment of QOL. Conclusion: Acne is a common adolescent problem. It is not only a cosmetic problem, but also has significant psychological impact. Evaluation of Quality of Life in patients with acne is important as it helps in the pharmacological as well as psychological treatment of these patients in a more effective and integrated way. Acne has an impact on Quality of Life (QOL) and evaluation of Quality of Life helps in the better ........