This study examines the impact of E-HRM on the performance of selected deposits money banks in Nigeria. Secondary data were used for the study which was obtained from annual financial statements of selected deposits money banks from 2006 to 2015. Bank Performance are measured using return on equity (ROE) which is dependent variable while E-HRM variables like e-recruitment, e-training, e-selection, e-evaluation, e-compensation and e-benefit are independent variables. Panel Data analysis technique was used to analyse the effect of independent variables on dependent variable. The study revealed that E-SELEC, E-TRAIN, and E-EVAL had positive significant effect on ROE (β=0.0359; 0.1436; 0.1611, t=0.009; 0.000; 0.001<0.05). Contrarily, E-RECRUIT, E-COMP and E-BENEF had negative significant impact on ROE (β=-0.1279; -0.0017 and 0.2231; t=0.012; 0.000; 0.003<0.05). Based on the empirical findings, it is concluded that E-recruitment, E-selection. E-training, E-evaluation, E-compensation and E-benefits are major determinants of E-HRM. Also, there is negative relationship between E-HRM and return on equity. Similarly, E- HRM had negative significant effects on Return on Equity (Bank Performance). It is now recommended that Banks should improve on their incentives to their staffs so as to facilitate higher employee performance in Nigerian Banking sector.