The approach to older adults with major neurocognitive disorder constitutes a challenge for families, this due to the lack of information to carry out this type of specialized care, and the scarcity of health professionals trained to facilitate an approach and Professional guidance on mental health in old age. In this sense, psychogerontological clinical practice is established today as an interdisciplinary field of study, due to the exhaustive knowledge about the sciences of aging and clinical psychology, for the evaluation, detection, rehabilitation, orientation and promotion of mental health with older people, family members and caregivers. Objective: To understand the experiences and perceptions of family members who care for older adults diagnosed with major neurocognitive disorder. In such a way, it allows to explore, understand and interpret about the knowledge about the appropriate approach, the risks of patient care and decision-making for coping. Materials and methods: a phenomenological-oriented qualitative study was carried out in an integral medicine unit, through the design and application of semi-structured interviews and observations of ten caregivers who attended the Psychogerontology service. Results: The informants stated that they did not have the necessary information to carry out adequate care for their relatives. However, the need for more professionals and social institutions to receive information is necessary. In this sense, they perceive their quality of life as poor, since they present the signs and symptoms of caregiver syndrome. Conclusions: Psychogerontological clinical care favors effective intervention in the approach to major neurocognitive disorder.