Huge fibroids are common presentations in our institutions. Abdominal myomectomy is the commonest method of treatment for those women. Preoperative anemia from menorrhagia and hemorrhage during myomectomy increases the need for perioperative homologous blood transfusion with its potential complications and risk for perioperative morbidity and mortality. The anesthetic technique that can reduce perioperative blood loss should be considered because of the reported association between anaesthesia type and risk of perioperative blood loss. All patients who had elective abdominal myomectomy for huge fibroids using the two main methods of anaesthesia (Regional (RA) and General (GA)) from January 2012 - December 31 2016 were retrospectively studied for type of anaesthesia, blood loss, need for blood transfusion and number of units of blood transfused. The technique was considered appropriate if it was a RA technique and was associated with a lesser blood loss, transfusion requirement and lower total number of units of transfused blood. Three hundred and fifty three (353) patients met the study’s inclusion criteria. One hundred and fifty (42.5%) patients had GA, while 203(57.5%) had RA. Mean blood loss was higher in the GA group compared to the RA group 593.2±486.6 and 410.8±316.7 respectively. Forty two patients in the GA group had a total of 57 units of blood while 23 patients in the RA group received a total of 29 units of blood preoperatively. Regional anesthesia was associated with significantly less blood loss and blood transfusion. Its use for myomectomy for huge uterine fibroids is very appropriate and should to be sustained.