Non-communicable diseases such as diabetes mellitus is a problem that needs to be considered by all levels of society because the diseases often increase morbidity and mortality. Generally, sufferers often experience behavioral changes including frustration, aggressive behavior, non-compliance in terms of treatment, anxiety about complications, and obstacles in socializing. This disease causes the patients to experience more stress known as diabetes distress. The Research aims to determine the factors associated with diabetes distress in patients with type 2 diabetes mellitus at the Aceh Tamiang Regional Hospital. The Study was conducted from March to July 2021 among 101 patients with Diabetes Mellitus Type 2. Data processing was carry results showed that the average distress value of type 2 diabetes mellitus patients was 2.71 (SD = 0.411), elderly (79.2%), male (65.7%), highly educated (64, 4%), married status (88.1%), long had diabetes mellitus (52.5%), had complications (67.3%), used oral medication (88.1%), not adhering to treatment (51.5%), did not receive family support (68.3%). Consequently, nurses are needed to educate sufferers concerning the complications of the disease both physically and psychologically.