Background: Use of multiple anesthetic agents to induce anesthesia is not new and they are used to achieve different effects such as sedation, muscle relaxation and pain relief. Thiopentone is the most widely used intravenous induction agent in current anaesthetic practice. Propofol is a new rapidly acting intravenous anaesthetic. The rapid redistribution and metabolism of propofol, result in a short elimination half-life. Midazolam is an imidazobenzodiazepine with relatively rapid onset of action and high metabolic clearance compared to other benzodiazepine. Objectives: T compare the induction characteristics of thiopentone, midazolam and propofol in elderly patients. Methods: A prospective randomized, double blind control study was conducted in the department of Anaesthesia at Shaheed Tajuddin Ahmad Medical College Hospital, Gazipur, Bangladesh from January to December-2020. Sixty three adult patients, aged between 55-75 years with ASA grade I & II Who were clinic trial in our department. The patients were divided into three groups of 21 each according to a randomization table. The overall performance of the drugs were assessed by recording the following parameters: 1. Pain on injection. 2. Induction time (The time from start of injection to the loss of eye lash reflex). 3. Coughing 4. Involuntary motor activity. 5. Apnoea (present/absent). 6. Haemodynamic changes (Heart rate and blood pressure at 2 min before injection, after induction and 1min, 3min and 5min after intubation). 7. Recovery time (From the end of reversal until the patient responded to vocal command (eye opening, tongue protrution). Results: The incidence of pain on injection was greater in propofol group (42.86%), which was statistically significant (p<0.01). The induction time was significantly longer (p<0.001) in the midazolam group. Incidence of excitatory effects was more common in propofol group (p<0.05). Incidence of apnoeic episodes were significantly greater in thiopentone and ............