Liver diseases are a major health burden globally. The sharp increase in obesity has led to a greater prevalence of nonalcoholic liver diseases. NAFLD may progress to NASH, cirrhosis of the liver, and even hepatocellular carcinoma. Alcoholic liver disease is also a common disorder, leading to alcoholic steatohepatitis and alcoholic cirrhosis. Alcohol abuse is a risk factor in about 50% of cases of cirrhosis. Cirrhotic patients may present with ascites, portal hypertension-related bleeding, or hepatic encephalopathy. They are also at a higher risk of developing hepatocellular carcinoma. Hepatic viral infections are also rampant. Hepatitis B viral infection is common, with almost 30% of the world’s population showing serological evidence of exposure. These patients can progress to hepatocellular carcinoma. HCV infections also can lead to cirrhosis and hepatocellular carcinoma. Chronic HCV infection is often the primary reason for having a liver transplant. It is estimated to affect over 58 million worldwide and is a major cause of liver disease-related death. No vaccination is available for HCV. Hepatocellular carcinoma is the sixth most common malignant tumor in the world. It is also the fourth leading cause of cancer-related death worldwide. It usually occurs in patients with a history of viral hepatitis, alcoholic hepatitis, or nonalcoholic fatty liver disease. Since its diagnosis is often made at late stages, mortality is high. Given the ominous nature of these liver diseases, prevention and management via lifestyle modification is an important option. This manuscript discusses five major modifiable lifestyle behaviors that can significantly impact liver diseases.