The dynamic environment and the capability of information systems is one of the challenges companies face in order to achieve effective performance. The purpose of the study was to determine the effect of Management Information Systems agility on the performance of commercial banks in Nairobi city County, Kenya. Commercial banks in Nairobi County have been performing poorly because of poor service quality, insufficient ICT literacy of bank employees, information system insecurity, inadequate information storage and government regulations. The objective of this study was to determine the effect of service quality, ICT literacy, system security and information storage on the performance of commercial banks in Nairobi County Kenya. The target population was 430 employees from 43 commercial banks in Nairobi County Kenya. Purposive sampling was used to draw a sample size of 86 ICT specialists as respondents. Primary data was collected through questionnaires. Data was analyzed using descriptive, relational, and inferential analysis especially use of regression model. The study found out that service quality, ICT literacy, system security, information storage were significant and had positive effect on performance of commercial banks. The study concluded that management information system agility has influence on the performance of commercial banks. The study recommended that commercial banks should formulate strategies that will enhance performance of commercial banks based on service quality, ICT literacy, systems security and information storage in their organizations.