Objective: It is to analyse the perceptions and representations of diabetes with alternative medicine in the Yeminkol culture of Soa, Centre Region of Cameroon. Methods: The study is purely qualitative with interviews administered individually at the respondents' homes simultaneously in the cities of Yaoundé and SOA in March 2020. The sample size consisted of ten informants: two health professionals, three radiotherapists, five members of the community predominantly former patients until saturation, i.e. until no new information was available, and sources of potential variation properly explored. Results: Representations and perceptions of diabetes in the Soa's Yeminkol socio-culture focused on the community member's knowledge of diabetes. It is anthropology of the inner body showing it works when it is healthy and how it works when it is unhealthy. Conclusion: In Yeminkol's socio-culture, each member of the community perceives and represents diabetes by referring to the cultural patterns of the society to which he belongs. He gives opinions on the history, origin, causes, and therapeutic routes. The perceptions and representations that diabetics have in this cultural universe are a concern because there is the refusal to accept this pathology thereby explaining the failure of medical care.