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Assessment of Clinico-Radiological Profile of Brain in Children with Developmental Delay

DOI : https://doi.org/10.36349/EASJRIT.2020.v02i04.001
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Background: Developmental delay denotes an extensive delay in one or more developmental domains. It has an estimated occurrence of 1-3% worldwide. Magnetic resonance imaging of the child's brain appears to be the most assuring neuroimaging technique in the evaluation and diagnosis of patients with the developmental delay disorders. Aims and Objectives: Our aim was to identify the spectrum of abnormalities in the brain by using MR imaging in children with developmental delay and also categorize all the morphological abnormalities. Secondly, the role of MR spectroscopy (MRS) to evaluate the severity and magnitude of different neurometabolite ratios in children with normal brain imaging were also studied. Materials and Methods: Our study involves the examination of 120 children presenting with developmental delay to the Department of Radiodiagnosis, Mamata Academy of Medical Sciences, Bachupally, Hyderabad, between July 2018 to June 2019. The children were examined with a standard MRI protocol. Clinical and demographic features and parameters were noted. The different brain structures involved were studied systematically, and the morphological abnormalities were categorized. Results: The occurrence of abnormal MRI findings was 78% among the evaluated children. Our study showed predominant involvement of the ventricles, white matter and corpus callosum. The marginal proportion of various morphologic abnormalities was Non-specific findings (11%), Neoplastic and cystic lesions (3%), Neurovascular diseases (50%), Congenital and developmental (12%) and combined aetiology (2%). Ten children with a normal MRI were subjected to MR Spectroscopy which revealed no significant difference in the neurometabolite ratios among the patients. Conclusion: MR imaging has good specificity and sensitivity in diagnosing various disorders of developmental delay. Careful evaluation of the MRI helps to identify the probable aetiology in most of the cases. Proton MR Spectroscopy is an advanced

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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