Introduction: Propofol, a popular intravenous anesthetic, is now on the trade. It's a common tool for both starting and keeping anesthesia going. Antiemetic and anticonvulsant properties and the speed of induction and recovery are its primary benefits. Intubation without a muscle relaxant, day surgery, and the installation of a laryngeal mask airway has all been effective using this technique. Injection discomfort, dosage-dependent hypotension, and severe bradycardia are the primary drawbacks of the drug's use. Objectives: Researchers set out to see how much of a difference complete intravenous anesthesia with Propofol made in mean systolic function roughly equivalent to balanced anesthesia (Thiopentone; Isoflurane; Nitrousoxide). Results: Multicentered based randomized quasi-experimental prospective study was performed in Kushtia Medical College Hospital, Kushtia, Bangladesh, from January 2019 to December 2020. In our study, out of 60 cases (30 in each group), 70 %(n=21) in Group-A and 63.33%(n=19) in Group-B were between 12-30 years of age while 30%(n=9) in Group-A and 36.67%(n=11) in Group-B were between 31-60 years of age, mean±SD was calculated as 27.90±8.91 and 29.8±8.49 years respectively. 60 %(n=18) in Group-A and 53.33%(n=16) in Group-B were male while 40%(n=12) in Group-A and 46.67%(n=14) in Group-B were females. Comparison of mean hemodynamic changes using Propofol as total intravenous anesthesia with balanced anesthesia technique (thiopentone isoflurane-nitrous oxide) shows that heart rate after intubation in Group-A was 83.4±2.36 and 90.36±1.95 in Group-B, the p-value was 0.001 while meaning arterial pressure in Group-A was recorded as 78.6±2.25 and in Group-B 89.43±1.73, the p-value was 0.000. Conclusion: A substantial improvement in supportive care is seen in surgical interventions when using Propofol as a complete intravenous anesthetic vs. balanced anesthesia (thiopentone-isoflurane-nitrous oxide).