Introduction: The study of mortality allows for the monitoring and review of therapeutic measures in a health facility. Maternal death is a major concern in the world and constitutes a social tragedy. We present a study on the etiologies of maternal death in the mother and child health center in the Zinder region. Methodology: This was a retrospective, descriptive study covering three years from January 1st, 2017 to December, 31st, 2019. The study was carried out at the mother and child health center in the Zinder region, the main regional referral site for obstetrics and gynecology. The objective was to determine the etiologies and epidemiological profile of deceased parturients. Patients admitted directly or evacuated from other health facilities and who died according to the definition of maternal death were included. Accidental and incidental deaths and those that did not meet the WHO framework were excluded. Data were collected from the admission register, the maternal death audit report and the patient file. The variables studied were epidemiological data, causes of death, mode of transport and length of stay of the patient. Results: A total of three hundred and ninety-seven (397) files were retained out of 13874 admissions, including 7606 live births. The mortality rate was 2.86% and the maternal mortality ratio was 5219.56 per 100,000 live births. The average age was 26 years with extremes of 15 and 45 years. The 25-29 year old age group was the most affected with 23.92% (n=95). Large multiparous women (6-13 parities) were the majority with 28.21% (n=135). Most patients (87.15) were evacuated and transported medically in 92.77%. They were from rural areas in 72.83% (305). More than half, 81.86% (n=325) were uneducated. The pregnancy was not monitored in 84.39% (n=335 cases). Management was immediate, in less than one hour in 70.78% (281 cases) of patients. It was provided by the midwife alone in 34.50% (137 cases) versus 26.44% (105 cases) by the ..........