CNS infections represent a wide spectrum of diseases, out of which fungal infections make a fare subset. In the last two decades, more frequent use of immunosuppressive therapies especially in patients with autoimmune diseases along with usage of chemotherapeutic agents in oncological patients has led to increase in the incidence of fungal infections. Occasionally the radiological manifestations overlap with that of primary brain glial cell tumors as seen in our case. A 20 years old female presented to a tertiary care cancer hospital with complaints of headache and vomiting for last two months. On imaging there was heterogeneously enhancing left frontal parasagittal mass involving genu of corpus callosum with surrounding vasogenic edema. There was adjacent meningeal enhancement also seen. It was favored to be a high grade glioma; however differentials of Cerebritis and focal infective lesion were also considered. MR Spectroscopy was interpreted as of intra-axial high-grade glial cell tumor. Burr hole biopsy samples were sent for histopathology revealed multiple scattered granulomas containing few giant cells representing fungal infection. Fungal infections usually manifests as intracranial extra axial lesions with heterogeneous or peripheral enhancement. The imaging findings overlap with that of high-grade gliomas and can be misinterpreted as in this case. Thus, it is important to have a good understanding of the radiological presentation as well as have a known how of the clinical presentations to reach to a better diagnosis.