Objective: To determine frequency and prognosis of stroke in patients with hyperglycemia in the acute phase at the Neurology department of Yalgado Ouedraogo Teaching University Hospital. Patients and methods: We conducted a 6 years cross-sectional study on acute stroke patients admitted in the neurology department of Yalgado Ouedraogo Teaching Hospital from 1st January 2011 to 30 June 2017. This study included only patients with hyperglycemia at admission (≥ 6.1 mmol/l). Results: The overall frequency of admission hyperglycemia was 7.27% with respectively 8 % in AIS and 6.1% in ICH. The overall mean age of patients with was 58.83 years. The majority of patients was male gender (52.6%). According to diabetes status, 70.8% of patients were known diabetics (39.4%), 31.4% new diabetics and 29.2% had stress hyperglycemia. The frequency of known diabetics was higher in AIS (p=0.000003) while stress hyperglycemia was most frequent in ICH (p= 0.0001). The majority of patients (74.5 %) had severe neurological deficit with NIHSS ˃15. Severe hyperglycemia (≥ 11.0 mmol/l) was present in 62.7% of patients. The majority of patients was treated with insulin (52.6 %) who was given alone mostly in AIS (p˂0.05). Patients who did not received any treatment were in the group of ICH (p˂0.05). The overall mean length of stay was 13.35 days. At discharge, 60.6% of patients were euglycemics. The overall mortality was 22.6% with higher mortality in ICH (p˂0.05). At discharge, the majority of survivors (69.3%) had worse functional outcome (mRS˃2). The factors influencing the mortality of AIS were known diabetes, severe hyperglycemia and no hypoglycemic agents (p˂0.05). In ICH, the mortality risk factors were previous diabetes, glucose level (7-7.7 mmol/l) and t combined hypoglycemic agents. Conclusion: Admission hyperglycemia in stroke is rare in our context. Stress hyperglycemia is most common in ICH. Insulin treatment was mostly used. Mortality rate of higher both in AIS and ICH.