The study aims to identify the innovation and integration of 4Cs in the educational system as the basis for support in the quality of teaching in the 21st century among the respondents in the area of critical thinking, creativity and innovation, communication process, and collaboration. The research employs a descriptive quantitative design because it relates to the study under investigation. It aims to quantify the innovation and integration of 4Cs in the educational system as the basis for support in the quality of teaching in the 21st century among the respondents in the area of critical thinking, creativity and innovation, communication process, and collaboration. Hence, random sampling technique is utilized in the study to represent the entire group of the population as a whole. The goal is to provide samples of the population and representative of the study as far as the number of population is concerned. The participants of the study are professional teachers in the various public and private institutions and are exposed to teaching experiences where they utilized the 4Cs in their teaching process. The study comprised fifty-five (55) respondents only. Results shows that innovation and integration of critical thinking reveal that students allow to think and to solve the problem by providing to boost and self-esteem the student opportunity to express themselves in the learning process and expand their critical thinking through proper demonstration of the right approach to learning that will create student to summarize their own interpretation to what is being taught in their learning process and enhancement, innovation and integration of communication reveal that it provides upliftment and achievement on the academic performance of students information and advancement which leads to their development in the learning process, innovation and integration of creativity reveal that it provides the proper thought and creativity through their imagination and .........