EAS Publisher | Antidiabetic Potential of G. Mangostana Extract and α-Mangostin Compounds from Mangosteen (Garcinia mangostana Linn.)

Antidiabetic Potential of G. Mangostana Extract and α-Mangostin Compounds from Mangosteen (Garcinia mangostana Linn.)

DOI : https://doi.org/10.36349/easjpp.2021.v03i05.001

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Background: Diabetes mellitus is a high prevalence disease that increases and requires continuous treatment. However, antidiabetic drugs can cause side effects in long-term use. Traditional medicine derived from natural sources such as mangosteen (Garcinia mangostana Linn.) is potential as one of the solutions as an antidiabetic drug. α-mangostin has an antidiabetic activity where this compound lowers blood glucose levels and normalize hyperglycemic conditions. This review summarized the antidiabetic activity of G. mangostana and α-mangostin compound in the mangosteen (G.mangostana Linn) plant. Method: We reviewed and compiled published articles search through several sites such as Google Scholar, NCBI, Pubmed, Research Gate, and Science Direct within the last ten years. Result: Several studies show an antidiabetic effect from G. mangostana and α-mangostin observed from several parameters, including blood glucose levels, plasma insulin, HOMA-IR values, histopathology examination, and others. Conclusion: G.mangostana extract and α-mangostin are promising candidates for the treatment of diabetes.

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