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Histological Study of Trachea Tissues of Rats Exposed to Cigarette and Waterpipe Smoking and the Ameliorating Effect by Ammi visnaga

DOI : https://doi.org/10.36349/easjvms.2021.v03i04.002
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Smoking remains a global health problem because it has negative impacts either on health or economy. Smoking has various forms or types of which cigarette and waterpipe smoking are mostly prevalent. The main objectives of the present study were to investigate the histological changes resulting from exposure to cigarette and waterpipe smoking on rat trachea, and to investigate the ameliorating effects of using Ammi visnaga in reversing the adverse effects of smoking. Animal smoking model was created based on male rats that were randomly assigned in to different groups (N=8). Groups included control group, cigarette smoking group, waterpipe smoking group, cigarette smoking group treated with Ammi visnaga, and waterpipe smoking group treated with Ammi visnaga. Smoking protocol was applied for 1 month. At the end of the experiment, animals were sacrificed, trachea was isolated and placed in formalin (10%) for fixation, and tissue sections were prepared using Hematoxylin and Eosin stain. Results showed that smoking either cigarette or waterpipe had negative impacts on tracheal tissue in terms of disruption of cilia, or amalgamation of cilia. Heavy infiltration of lymphocytes was observed. The use of Ammi visnaga showed health effects by lowering the infiltration rate of lymphocytes and partial recovery of epithelial cells and reversing impacts on cilia. Taken together, this study, May for the first time, showed the importance of using Ammi visnaga in the improvement of histological changes induced by smoking models on tracheal tissues of smoking rats.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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