Introduction: Acne vulgaris is a common skin disease that can adversely affect the quality of life of patients. Acne is a chronic disease, involving the face affecting more than 85% of the teenagers, as well as some adults. Though it is considered to be merely a cosmetic problem, it is associated with considerable psychological impairment which is comparable with certain chronic diseases like asthma, epilepsy, diabetes and arthritis. Objective: To assess the impact of acne on Quality of Life and acne vulgaris is a chronic disease affecting the face in adolescents and adults. Material and Methods: The study sample consisted of 451 consecutive patients with facial acne vulgaris. Patients who had attended the Dermatology OPD, Medical College for Women & Hospital (MCW&H), Uttara, Dhaka, Bangladesh were included in the study. The study sample consisted of 451 consecutive patients with facial acne vulgaris who had attended the Dermatology OPD over a period of 6 months from January to June-2020. After obtaining the history, the acne was graded into mild, moderate and severe based on the type and number of lesions. Dermatology Life Quality Index (DLQI) and Cardiff Acne Disability Index (CADI) were administered on the patients to measure the Quality of Life. Results: Majority (55.65%) of the study population was between 16-20 years and the number of males was more than the number of females. Most of the patients were educated and unmarried. 62.31% of patients belonged to the urban areas & (61.20%) had an acne duration of >1 year. Severe acne was seen in 25.27% of patients and 52.10% had a moderate grade of acne. In 300 patients (66.52%) the CADI scores were >8 showing a clear impact on QOL. Based on the DLQI scores 76.93% of the patients had a moderate to extremely large impairment of QOL. Conclusion: Acne has an impact on Quality of Life (QOL) and evaluation of Quality of Life helps in the better management of patients with acne.