The occurrence of Soil Transmitted Helminths (STHs) and Helicobacter pylori among children in Port Harcourt Children’s home was investigated. Faecal and blood samples were collected from the participants. The faecal samples were examined for the presence of STHs using the direct smear and modified acid fast staining techniques while the blood samples were serologically investigated for the presence of H. pylori using the H. pylori IgG antibody kit. Out of the 99 children examined, 14(14.1%) and 54(54.5%) were positive for STHs and H. pylori respectively. The STHs identified included Hookworm (35.7%), Trichiuri trichiura (35.7%) and Ascaris lumbricoides (21.4%). Double infections of A. lumbricoides + H. pylori (21.3%), Hookworm + H. pylori (35.7%), T. trichiura + H. pylori (35.7%) and mixed infection of A. lumbricoides + Hookworm + H. pylori (7.1%) was recorded. The occurrence of H. pylori in relation to sex, age and level of education among the children showed no statistical significance (p < 0.05). Health education of the children and sustenance the policy and health strategies that ensure low prevalence of the infections should be encouraged. Furthermore, there should deliberate action plan to improve on the availability and accessibility to healthcare in the study area.