Background: Laparoscopic surgery is among the routinely performed surgeries. However, it leads to hemodynamic instability with potentially harmful consequences. Dexmedetomidine is found to provide good hemodynamic stability required during laparoscopy when performed under general anesthesia. The aim of the study was to assess the efficacy of dexmedetomidine in attenuation of hemodynamic responses. Method: A prospective comparative study was conducted at a tertiary care center, Kolhapur including a total of 60 patients between 18-60 years and belonging to Grade I and II as per American society of Anesthesiologists (ASA) who underwent laparoscopic surgeries under general anesthesia. All the patients were equally randomized and infused with either dexmedetomidine (Group D) or 0.9% saline (Group S) and baseline hemodynamics were recorded prior to the administration of general anesthesia. Post-operative requirement of analgesia (within 24 hours) and the recovery time were recorded. Outcomes of both the groups were compared by Chi square and a P-value <0.05 was considered significant. Result: No significant difference was found in preoperative heart rate and Mean Arterial Pressure (MAP) in both the groups (P= 0.8994; P= 0.5643, respectively). Post intubation, heart rate and MAP were significantly lower throughout the surgery, in group D (P<0.05). Requirement of isoflurane and incidence of hypertension were significantly higher in group S (P= 0.0031) whereas the requirement of post-operative analgesia were significantly less group D (P=0.0015; P=1.51e-08 respectively). Conclusion: Perioperative IV dexmedetomidine is very useful in stabilizing haemodynamics in patients undergoing laparoscopic surgeries under general anesthesia.