Background: Hepatitis E virus is an inflammation of the liver caused by Hepatitis E virus, which has a faecal- oral transmission route and it infect many people nowadays. Aim: This study aimed to design a vaccine that can cause protection from the Hepatitis E virus mainly in the Capsid protein including the cellular and humeral immunity (B-cell and T-cell epitopes). Methods: After retrieval of the sequence for the two proteins from National Center for Biotechnology Information (NCBI) BCEpred and ABCpred were used for B cell epitopes. NetMHC 4 serverwas used for T-cell MHC class I. For MHC class II ProPred severs was used. To a identify the antibody prediction epitopes for linear and discontinuous epitopes IEDB Ellipro tool was used. To identify the allergenicity Aller Top server and Vaxijen 2 server were used. For the toxicity Toxinpred was used. A 3D structure modeling was done using I-Tasser server. To visualize the two proteins a Docking process by ClusPro server to predict how HDAg protein binds with the receptor of the immune system. Results: BCEpred showed 54 epitopes and ABCpred showed 60 epitopes for B cell, for T cell 185 epitopes of NeTMHC 4 MHC class I and 42 epitopes of Propred MHC class II. All epitopes wee antigenic and no allerginecity detected. Also no toxicity detected, allowing to be used as a vaccine showing antibody prediction mode. Conclusion: In conclusionthis study proposed54 epitopes in the humeral response and 185 in cellular response that could be a powerful multi Capsid epitopes vaccine againsthepatitis E virus. Clinical trial is needed to proof the efficacy of these epitopes as promising candidate vaccine against hepatitis E virus.