EAS Publisher | Liquid Biopsy and Next-Generation Sequencing Technology to Improve Cancer Diagnosis, Prognosis, and Treatment

Liquid Biopsy and Next-Generation Sequencing Technology to Improve Cancer Diagnosis, Prognosis, and Treatment

DOI : https://doi.org/10.36349/easjbg.2020.v02i01.001

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Cancer is a disease that has positioned itself as the second cause of death globally. However, there is a deficiency in diagnostic tools and treatment. Traditionally, biopsy involves tissues extraction to be examined. But, it is an invasive procedure and can lead to complications in patients. Liquid biopsy has been developed as a non-invasive technique, with lower cost and allowing a better diagnosis. As a complement, new-generation sequencing (NGS) allows information sequencing and analysis from DNA. The combined use of these tools can result in identification of genetic aberrations in cancer, improving of patients´ prognosis, and use of personalized therapies when studying an individual´s genomics, epigenomics, and proteomics profile. Despite these advances, there are elements to improve procedures sensitivity, a better understanding of biochemistry and immunological response in tumorigenesis processes, and integration of this data through computational strategies for the development of tumor profiles

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