Background: Coronavirus pandemic is undeniably in the focus of worldwide attention, specific influences on the magnitude of negative psycho-socio-economic outcome. Aim: The study aims to explore the psychosocial effects of lockdown measures among the Sudanese population during the COVID-19 pandemic and the coping strategies used. Methods: A descriptive web-based method was used. The data were collected through the survey questionnaire designed on free Google forms software. A snowball technique was used to recruit the participants from different social media platforms. The data analyzed by (SPSS). Results: A total of 1811 Sudanese citizens were responded from different Sudan states. The findings revealed that the majority 53 % were experiencing fear of the unknown, frustration, and isolation, around 52 % feeling sad and depressed. Majority 64% reported reduced livelihood opportunities. 69% reported that the lockdown could negatively affect students ’academic performance. Some positive effects were identified among respondents including an increase in positive relationships within family members. The most coping strategies used was getting closer to God with prayers, reading the holy Quran. Engagement in physical exercise, follow all necessary instructions to protect themselves and others, 66% spending time on social media, connecting with others. The study indicated a significant association between psychological effects of lockdown on Sudanese people such as age, gender, and occupation. Also, a significant association between age, occupation, and source of income, and the social effect of lockdown. No significant association was found between socio-demographic data and coping strategies. Conclusion: Our study concluded that the lockdown due to the COVID-19 pandemic had indeed adversely affected the majority of Sudanese respondents in psychological, social, and economic well-being. Different positive coping strategies used to reduce the stress and to adapt to ......