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The Impact of Genomic Science on Society & the Discovery of AZQ (US Patents 4,146,622 and 4,233,215) rationally Design to attack Glioblastoma, The Brain Tumor

DOI : https://doi.org/10.36349/easjbg.2021.v03i03.002
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This abstract describes the Genomic Impact of science on society. How progress in Genomic has provided us enormous benefits for designing drugs like AZQ to treat brain cancer and at the same time raised some serious ethical problems. Instead of finding new treatment of cancers by the old trial-and-error methods, we are developing rational drug design to treat cancers based on the genetic make-up of a specific disease. Sequencing Human Genome has identified 24,000 genes that provides total information to make us. In our genome, we carry 16,000 good genes that code for good proteins that keep us healthy. There are 6,000 bad or mutated genes responsible for causing six thousand different diseases. There are 2,000 Pseudogenes that have lost their functions because they are no longer in use. The 6,000 mutated genes are damaged by radiations, chemical or environmental pollution, viral infection or genetic inheritance. The mutated genes code for wrong proteins which make them responsible for causing diseases. For example, when we sequence a bad gene and compare with the Reference Sequence, we could easily identify the location of the mutated gene on a specific chromosome. The rational drug design requires that we synthesize drugs based on the genetic make-up of the sequence. AZQ (US Patents 4,146,622 and 4,233,215) was rationally design to attack Glioblastoma, the Brain Tumor. This abstract present not only the discovery of AZQ, but also presents some possible solutions to serious ethical problems.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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