Background: With the advent of treatment like chemotherapy and radiotherapy, survival rates of many cancers have increased, but patient may experience side effects from the disease itself and/or from treatment for the disease which can eventually hinder patient’s quality of life. Aim and Objective: To assess the quality of life among cancer patients in relation to type of treatment (chemo therapy vs. radio therapy). Material and methods: It was a cross sectional, descriptive and hospital based study. Total duration of study was 6 months (January 2020-Jun 2020), conducted in Dept. of Clinical Oncology, Enam Medical College & Hospital, Savar, Dhaka, Bangladesh. A total of 113 cancer patients undergoing treatment were selected as study subjects out of which 64 were undergoing chemotherapy and 49 were undergoing radiotherapy. Participants were interviewed by a validated questionnaire. Results: A total of 113 cancer patients were included in the study, of which 67 (59.3%) were females and 46 (40.7%) were males. None of the participants had above average or significantly high quality of life. 22.1%, 54%, 21.9% had average, below average and significantly poor quality of life respectively. Patients undergoing radiotherapy had a comparatively higher quality of life than patients undergoing chemotherapy (p value <0.05). Among patients undergoing chemotherapy, those who have undergone 3 or more cycle had better quality of life than those with less than 3 cycle (p value-<0.05). Conclusion: Our study showed that majority of cancer patients undergoing treatment had poor quality of life and among them patients undergoing chemotherapy had lower quality of life compared to patients undergoing radio therapy.