Background: Treatment of gall stones have evolved markedly since open cholecystectomy was first described by Langenbuch in 1881. Management has progressed through eras of nonsurgical management, laparotomy, minilaparotomy and now laparoscopic cholecystectomy which is the gold standard for the treatment of gall stone disease today. Methods: This comparative randomized study was conducted at Nimra Institute of Medical Sciences between November 2019 to October 2020. 100 consecutive patients who fit into the inclusion criteria were included in the study. 50 patients were included in the multiport cholecystectomy arm and 50 in the single port cholecystectomy arm. Random allocation of patients presenting with symptoms suggestive of gall bladder disease with confirmatory USG study was done to the two groups using the sealed envelope technique which was opened just before the skin incision. Results: Significant difference in the conversion rate was found in the two groups the conversion rate for single port cholecystectomy was 12%. No statistically significance rise in surgical complications occurred in the patients operated by single port technique as compared to multiport surgery. Median time required to complete cholecystectomy by single port technique was significantly higher than that required for multiport cholecystectomy. No difference was found in the duration of postoperative pain experienced in the two groups. Postoperative complaints of nausea and vomiting occurred in almost equal number of patients in the two groups. Patients operated by single port technique had a postoperative hospital stay of mean 2.12 days, almost same as for patients operated by multiport technique. Conclusion: Technical difficulty and inflammatory changes due to chronic cholecystitis are the leading causes of conversion from single port to multiport cholecystectomy. Time required for single port surgery is significantly higher than multiport cholecystectomy. Postoperative port site .......