Background: Liver cancer is the 10th most prevalent cancer in the United States, and its occurrence has been raising for many decades. Early identification, diagnosis, and management of diseases are crucial. Computed tomography (CT) is among the most effective and reliable imaging methods for detecting liver lesions and different tumors. CT scanners can perform multiple-phase continuous scan of the entire liver. Objective: To determine the accuracy of triphasic computed tomography in the differentiation between benign and malignant focal liver lesions in patients observed and selected in Gondal medical and diagnostic complex, Gujranwala. Materials and Methods: An observational and cross-sectional study performed at Gondal medical complex and diagnostic center Gujranwala, Pakistan. Total 100 patients were observed during the period of this study and the data of 60 relevant patients were collected on the basis of inclusion criteria set for this study. Results: In this study of 60 patients, males were dominant (56.7%) than females (43.3%). The most dominating age of patients in the study was 41-55 years which accounts for 40% of entire sample. About 38 patients (63.3%) showed increased level of AFP between 401-500ng/ml. Out of 60, 17 patients (28.3%) were diagnosed with benign focal liver lesions and 43 patients (71.7%) were diagnosed with malignant focal liver lesions through different enhancement patterns. The most common malignancy in the current study was HCC and all the patients diagnosed with HCC had an ultrasound detected history of Cirrhosis and CLD. Conclusion: It is concluded that Triphasic CT scan is first line and non-invasive imaging modality which efficiently differentiated benign focal liver lesions from malignant focal liver lesions and the study evidently concluded that raised AFP level is associated with malignant focal liver lesions mostly with HCC.