Pesticides from decades are used not only in the agricultural fields for the increase in food production but also for public health protection. More than 1000 different organic and inorganic compounds are used as pesticides. Most widely used pesticides are organochlorine pesticides, which are not only toxic but persist in the environment for decades and are bio accumulated. Uncontrolled use of pesticides, their persistence results in the pesticide residues or related daughter products in the soil, surface water, groundwater, air, and in primary and derived agricultural products. Due to consumption of pesticides contaminated rations and use of the pesticides on the animals to control ectoparasites, application of pesticides on fruits and vegetables to control pests lead to the presence of pesticides in milk, vegetables, and fruits. For the survival of any humankind milk, vegetables, and fruits play a very important role as they are the sources of vitamins, carbohydrates, essential trace metals, antioxidants. The accumulation of the pesticides in food products adversely affects human health ranging from short term to long-term impacts. Headaches, nausea, asthma, sore throat, eye irritation, skin irritation, diarrhoea, pharyngitis, nasal irritation, sinusitis, contact dermatitis, inflammation, endocrine disruption are some short-term effects of pesticides to human, while long term exposure may cause birth defects, infertility, endocrine disruption, depression, diabetes, neurological deficits besides cancer. This review aims to report the concentration of the commonly used pesticides in animal milk, human milk, fruits, vegetables, grains and their impact on human.