Peptic ulcer is in the study for centuries. A peptic ulcer is the formation of sores and ulcer in the stomach and duodenum. The two main types of peptic ulcer are gastric ulcer and duodenum ulcer. It is the multifactorial health problem in the past century; its popularity and risk factors have changed a lot. The population is suffering from a peptic ulcer is about 4%. About 10% is the risk in the duration of a person life. To aim at the different risk factors of peptic ulcers in this systematic review with reference to the literature. Medlin, Embase, Science Direct, Google Scholar, and books were used to collect the data. Data were collected from studies published between 2015-2020, and the studies published before 2015 were excluded. Studies were reviewed manually by their abstract and by full text. H pylori and the use of NSAIDs are the main risk factors for developing peptic ulcer disease. Studies showed that the risk of peptic ulcer disease is double in the people with these risk factors. The result of this review concluded that the administration of all these risk factors contributes to the increase in the number and severity of peptic ulcers. According to the results, by overcoming all these risk factors and improving our health and living standards, this disease can be cured.