Abstract: Introduction: Colonoscopy may be a mildly painful procedure requiring conscious sedation. Though propofol may be a widely used anesthetic in day-care procedures thanks to its rapid onset and quick recovery features a drawback of requiring resuscitation maneuvers more often than the traditional methods. Dexmedetomidine, a newly introduced, highly selective α2 adrenergic receptor agonist possessing hypnotic, sedative, anxiolytic, sympatholytic, and analgesic properties with impressive margin of safety, must be explored to be used in conscious sedation for colonoscopy procedure among Bangladeshi population. Objective: To find out the comparison between propofol and dexmedetomidine for conscious sedation in patients undergoing outpatient colonoscopy. Materials and Methods: A prospective randomized comparative study was conducted on patients aged between 25 and 60 years with the American Society of Anesthesiologist physical status classes I and II posted for colonoscopy under monitored anesthesia Dept. LABAID Specialized Hospital, Dhanmondi, Dhaka, Bangladesh from January 2018 to December 2019. Study group was randomly divided into two groups and administered propofol and dexmedetomidine. The primary outcome variable was assessments of sedation scores between the two groups. Secondary outcome variables were pain score assessments, hemodynamic comparisons, and adverse events among the two groups. Appropriate statistical tests were applied to compare the findings. Results: After comparisons between the two groups, we found that...................