Abstract: Background: The coronavirus crisis has challenged higher education institutions in many new and unexpected ways a growing number of universities across the world have either postponed or canceled all activities and precautionary measures have been taken to safeguard students and staff members from highly infectious diseases. Aim: To assess the effects of university closure during the outbreak of COVID-19 on the academic, psychological, and social status of health professional students. Methods: A descriptive cross-sectional study was conducted at Alzaiem Alazhari University among health profession students from April to July 2020. The subjects of the study who amounted to 298 were selected using the convenience sampling technique. The data were gathered through an electronic questionnaire and analyzed using SPSS software. The results were displayed as frequency and percentage, a statistical test was used and the level of statistical significance was calculated by chi-square and P values (≤ 0.05). Results: There was a significant effect of university closure during the outbreak of COVID-19 outbreak on academic performance. (80.5%) of the participants did not study and review their previous courses during the closing period of the university, and also on the psychological well-being of the candidates. (92%) became anxious and worried about their academic and professional future and on social status, as (89%) increased the number of hours spent on social media during university closures. all p-values were less than 0.05. Conclusion: The study concluded that university closure during the outbreak of COVID-19 had a negative impact on the academic performance and psychological well-being of health profession students.