Abstract: Introduction: Brain abscess is a life threatening disease that present a formidable challenge to the physicians. Despite the development of effective antibiotics & modern surgical techniques significant mortality & morbidity persist among patients with CNS infections. Aim of the study: To assess the CT scan findings, sensitivity and specificity of CT scan in the diagnosis of brain abscess. Material & Methods: This cross sectional consecutive observational study was conducted at the Department of Radiology and Imaging of Rajshahi Medical College Hospital from January, 2018 to December, 2018. Fifty-five (55) patients were selected using consecutive, non-randomized and open sampling method considering the inclusion and exclusion criteria. All the relevant data were collected, compiled and then organized by standard appropriate statistical formulae. Statistical analyses of the results were obtained with Statistical Packages for Social Sciences (SPSS-13). Statistical tests for significance of difference were done using t test, chi square test, or 'Z. test where applicable. A 'p' value < 0.05 was considered as significant. For Z test of proportion window based computer software devised with MINIT AB-12 was used. Results: The age range was from 11 to 65 years and the mean ±SD age was 34.18±16.81 years. Statistical analysis of patients of both sex has revealed that they were within similar age distribution (p value= 0.385). Single lesion was present in 83.6% patients and 16.4% had multiple lesions in the brain. 94.5% patients had abscess in gray-white matter junction and rests had within white matter. A total 52.7% patients had brain abscess on right cerebral hemisphere followed by 43.6% on left hemisphere and 3.6% had on cerebellum. 94.5% lesions were hypodense on CT and rests had both hypo and isodense feature. Ring enhancement and surrounding edema were the most common characteristic CT features in the diagnosis of brain abscess. Conclusion: Culturally and cyt