Abstract: This study aims to investigate and examine the influence of health related variables, socioeconomic factors and environmental indicators on the health status of East African countries which is proxied by life expectancy and assesses the link between public health intervention and health outcomes. Panel dataset from 2000 to 2016 for 11 East African countries was used to estimate the results. Nine variables related to health, socioeconomic and environmental factors that are predicted to potentially influence life expectancy are selected based on the available literature. To ensure the robustness of the result of the study, two estimation methods, which are widely used with panel data analysis namely; Pooled OLS and Fixed and Random Effects models are used. The estimation results suggest that under five mortality rates, HIV prevalence, the practice of open defecation, and carbon dioxide emissions have a negative and statistically significant effect on life expectancy. On the other hand, access to basic drinking water, immunization against measles, net official development assistance and foreign aid as well as urbanization has statistically significant positive effects on life expectancy. Furthermore, assessment of the linkage between the regression results and public health intervention confirms the need for a concerted and coordinated public health intervention strategy to address population health problems and strengthen and maintain the achievements in healthcare outcomes, observed in the study period, in the East Africa region.