Abstract: Background: The “therapeutic communication” as a concept needs clarification to enable clarity in the definition and to enable nurses and other healthcare providers to better understand this concept. Aim: To conduct a concept analysis on unconscious patients related therapeutic communication of nurses. Method: A Walker and Avant’s concept analysis method was used to clarify the concept's context, alternate terms, antecedents, attributes, and consequences. Data Source: Literature review was conducted using keywords from the concept analysis topic in English databases from the (EBSCOHOST, Medline via PubMed and Google Scholar search) for relevant studies. No restriction of time was enforced on publication date. Inclusion criteria included peer reviewed articles. Twelve (12) articles that met the inclusion criteria were included in the study. Results: Unconscious patients therapeutic communication can be defined by five attributes: "a means in building interpersonal relationships", "a process of information transmission", “An important means of clinical competency", "a structure with two different sections" i.e., verbal and nonverbal communication and "a significant tool in patient-centered care". Antecedents of the unconscious patients therapeutic communication of nurses included education and clinical practice, receiving feedback during clinical practice and application of theoretical knowledge, and skills such as listening and empathy while respecting interpersonal space. Conclusion: The findings of this concept analysis clarify the need for nurses in their training programs to have the necessary competencies to support the inability of unconscious patient’s therapeutic communication and build on interpersonal relationship.