Abstract: Indonesia is known as one of the countries that has a wealth of natural resources that can be used as herbal medicines. One of them is (Uncaria gambir (Hunter) Roxb). Gambir has been known to have many properties for various disease treatments. This article explores the traditional uses of gambir and seeks information about the phytochemical content of its pharmacological effects. In compiling this review article, tracing has been carried out in the form of national and international journals in the last 20 years (2000 - 2020). The main references used in this review article were searched through trusted websites such as ScienceDirect, ResearchGate, Google Scholar, and other published and trusted journals. Phytochemically, this plant contains catechin compounds, catechic acid, pyrocatechol, quercetin, tannins, flavonoids, gambirin alkaloid compounds, fluorescence gambir, tannin gambir, wax, rinkophylline, isorinkophylline, gambirdin, isogambirdine and auroparin. Pharmacologically, this plant has been reported to have antibacterial, anticancer, anti-inflammatory, antioxidant, anti-diabetic and hypoglycaemic effects. Traditionally, gambir is used as a mixture of medicines, namely for burns, headaches, diarrhoea, dysentery, canker sores and skin pain medication.