Abstract: Background / Objective: ∆(9) - Tetrahydrocannabinol (THC) is identified as the major active component of marijuana, it can interact with several pharmacological targets by involving cannabinoid receptors. Up to this point, many studies have proven that THC has many benefits with different mechanisms of action. This review aims to examine pharmacological effects contained in the ∆(9) - Tetrahydrocannabinol compound that can be used by medical field for treatment. Methods: We summarized the studies on the pharmacological properties of THC compound published from 2010 to 2020 from database such as PubMed, ScienceDirect, and Google Scholar. The search terms that were used are as follows: "∆(9) -Tetrahydrocannabinol OR Tetrahydrocannabinol" AND "Potential OR Properties OR Pharmacological OR Effects". Results: The results of 15 studies were included in this review based on our eligibility criteria with 6 animal studies, 4 human studies, and 5 in vitro studies that showed THC compound has many pharmacological effects, where the benefits of those effects are useful in the treatment. Conclusions: THC has potential in its use as analgesics, anti-inflammatory, anticancer, anti-nausea and vomiting, anti-tumor, hepatoprotective, and an indication of immunosuppression. More research is needed to evaluate the pharmaceutical potential of THC and the better comprehension of its pharmacological mechanisms.