Abstract: Alcohol use continues to be an important global public health problem and adolescence is a period of developing drinking habits. The use and abuse of alcohol by adolescents is on the increase in most African countries and is closely associated with risky behaviours, STDs and mental disorders in adult life. This study aims to identify predictors that may significantly be associated with alcohol use among secondary school students in Calabar South Local Government of Cross River State. A cross-sectional analytical survey was conducted to identify predictors of alcohol use among secondary school students in the study area. A multistage sampling technique was used to select 5 out of 33 secondary schools. A sample size of 370 was calculated using Cochran formula. Data was collected from 370 respondents using semi-structured self-administered questionnaire administered using a proportionate allocation technique among the respondents. Mean age of respondents was 14.89 ± 2.19 years, with 203 (54.9%) between the ages of 11 and 15 years. One hundred and sixty-eight (45.4%) of the students drank alcohol, with the majority of consumers being SSS2 students, 60 (16.2%). The predictors of alcohol used in this study were: respondent’s ages, 11-20 years (p = 0.008), respondent’s type of school, public school (p = 0.025) and respondent’s class, SSS2 (p = 0.035). Parents, schools and health authorities need to create more awareness on the hazards of alcohol drinking. Policy makers should enforce the laws regulating drinking age, with particular focus on adolescent drinking.