Nutrition research in sickle cell disease (SCD) has clearly demonstrated the impact of the physiopathology of this disease on the various nutritional elements essential of the health. SCD has also been associated with decreased dietary intake which results in poor nutritional status and impaired growth. The objective of this work was to assess dietary intake, body composition, and diet quality and blood macronutrients level of sickle cell patients in Yaounde, Cameroon. Height, weight, waist and hip circumferences were measured to get the Body Mass Index (BMI), waist to hip ratio (WHR) and daily energy expenditure. A 24-hour food recall, a weekly food consumption recall and a 7-day food record were done via questionnaires to get the food diversity scores, food consumption scores, daily macronutrient intakes and daily energy intakes. Blood serum was analysed for total proteins, albumin, globulin, glucose, triglyceride, total cholesterol, HDL cholesterol and LDL cholesterol content using colorimetric methods. Sickle cell patients were found to be underweight with an average BMI of 18.48 ± 2.02 kg/m2 and an overall ratio of 42.59% of underweight against 57.41% normal. Comparing gender, average BMI for males (19.00 ± 1.84 kg/m2) fell in the normal range of BMI and was statistically higher (P<0.05) than that of females (17.80 ± 2.07 kg/m2) corresponding to underweight. Waist to hip ration had an average value of 0.89 ± 0.05, with more than half of the participants (53.49%) suffering from figurative abdominal obesity corresponding to splenomegaly. Concerning the food quality, more than half (58%) had a low food diversity score. However, all participants (100%) had an acceptable food consumption score. The participants had abnormally low levels of total protein, globulin and albumin in blood with no significant difference (P>0.05) according to age or to gender.Proteins intake were normal, carbohydrates intake was slightly higher than the normal whereas the biochemical analy