Abstract: Introduction: “Pharmacovigilance”: As per World Health Organization (WHO), “Pharmacovigilance is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug related problems”. An adverse drug reaction (ADR) has been defined as ‘“any response to a drug that is noxious and unintended and that occurs at doses used in man for prophylaxis, diagnosis or therapy, excluding failure to accomplish the intended purpose”. Materials and Methods: This is cross-sectional, observational, questionnaire based study was carried out to evaluate the Knowledge, Attitude and Practice (KAP) among nurses/midwives working at Noor Hospital, Indian Institute of Medical Science and Research a tertiary care center towards ADRs and pharmacovigilance. Results: In our study, a total of 70 nurses/midwives were responded and involved in the pre - KAP and post- KAP survey questionnaires. The overall response rates between pre-intervention and post intervention was statistically significant nurses/midwives (P value <0.001) shows that effectiveness of educational intervention for improving awareness of pharmacovigilance among nurses/midwives. Conclusion: In conclusion of this study, the nurses/midwives had a relatively better attitude but lack of knowledge and least practices towards ADRs and Pharmacovigilance. The findings of the study suggest that there is need for continuous education and sensitization regarding Pharmacovigilance and ADR reporting system to nurses/midwives that improving the ongoing Pharmacovigilance activities in our hospital.