This study aims to determine the effect of feed substitution with the ingredients of bran and epidermis of Enzi matis cocoa on the hybrid duck blood profile. The method used was an experimental method with Complete Randomized Design (CRD) of 5 treatments and 5 replications. The treatment consists of P 0 = b ekatul 10% + 0% cocoa husk, P1 = bran husk 7.5% + 2.5% cocoa, P2 = bran 5% + 5% cocoa husk, P 3 = bran 2 , 5 % + cocoa shells 7.5 % and P4 = bran 0% + cocoa shells 10% . Feeding is done by self-mixing according to the treatment and feeding is done by dry feed. Cocoa epidermis used were from previous studies which gave the best results at an enzymatic 0.026%. The variables measured in this study included total blood cholesterol, triglycerides, LDL and HDL. Data were analyzed using ANCOV A. The results of this study showed that the enzymatic bran and cocoa substitution in the feed was able to give significantly different results (P < 0.05%) on the total blood cholesterol value and the results were very significantly different (P < 0.01 %) on triglycerides, LDL and HDL. The conclusion of this study is the use of enzymatic cocoa shells as bran substitutes can give good results at a percentage of 10%.