EAS Publisher | Morphormetric Analysis of Prostate of Castrated Sprague –Dawley Rats Treated With Combined Testosterone and Estradiol

Morphormetric Analysis of Prostate of Castrated Sprague –Dawley Rats Treated With Combined Testosterone and Estradiol

DOI : https://doi.org/10.36349/easjvms.2019.v01i01.001

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Abstract: The restorative effect of testosterone (t) and estradiol (e) on the prostate of castrated sprague-dawley rats was studied after four weeks of treatment using stereological and morphometric assessment method. Combined doses of t (3mg/kg bw.) and e (200µg/kg bw) administered for four weeks, caused rapid growth of the prostate. There was a significant increase in the volume density of the epithelium [vvep] by 1.8 fold in t alone treated group and 2.3 folds in combined t and e treated group. There was also a significant decrease of the volume density of acinar parenchyma [vvap] by 3.5 fold in both t alone treated group and combined t and e treated groups when compared with the castrated control. The growth of the acinar parenchyma and connective tissue especially of the epithelium were the dominant pattern recorded. This work showed a significant restorative response of the connective tissue and glandular epithelium of the prostate of castrated rats treated with combination of t and e.

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